Ralph H. Isham and Annie-Laurie Isham have listed for sale a six-bedroom, eight-bath home at 231 Little Noyack Path in Watermill for $17.5 million.

The 6,800-square-foot house was built in 2004. Susan Breitenbach of Corcoran Group is the listing agent for the house.

Mr. Isham is the founder and has been the managing director of GH Venture Partners LLC, an investment firm, since 1990.

He previously was a consultant to corporate management with The Boston Consulting Group and with Strategic Planning Associates. He also was a director at the American Stock Exchange. He is a co-founder of the International NeuroTrauma Research Organization in Vienna.

He is a trustee of the Institute for War and Peace Reporting, headquartered in London. He received a B.A. in international relations from Yale University and an M.B.A. from Harvard Business School.

The Ishams both serve on the board of the National Center for Victims of Crime in Washington, which Ms. Isham and her brother, Alex, founded in 1985.

Ms. Isham is the former president of the Sunny von Bulow Coma and Head Trauma Research Foundation. She previously was the co-producer of PBS special "Drinking & Driving: Severe Head Injury," and she hosted the PBS special "The Journey Back: Surviving Coma."

According to BlockShopper.com, there have been 46 home sales in Watermill during the past 12 months, with a median sales price of $2,471,250.